What is the effect of corticosteroids on wound healing?

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Multiple Choice

What is the effect of corticosteroids on wound healing?

Corticosteroids slow wound healing by dampening both the inflammatory and proliferative phases. They blunt the inflammatory response by reducing leukocyte migration and cytokine signaling, which slows debris clearance and the recruitment of cells needed for repair. They also directly inhibit fibroblast activity and collagen synthesis, and they decrease angiogenesis, so the formation of granulation tissue and new extracellular matrix is delayed. Because less collagen is deposited, wounds take longer to close and have reduced tensile strength, though scar formation is typically diminished. In short, they suppress inflammation and collagen production, leading to delayed healing and less scar tissue.

Corticosteroids slow wound healing by dampening both the inflammatory and proliferative phases. They blunt the inflammatory response by reducing leukocyte migration and cytokine signaling, which slows debris clearance and the recruitment of cells needed for repair. They also directly inhibit fibroblast activity and collagen synthesis, and they decrease angiogenesis, so the formation of granulation tissue and new extracellular matrix is delayed. Because less collagen is deposited, wounds take longer to close and have reduced tensile strength, though scar formation is typically diminished. In short, they suppress inflammation and collagen production, leading to delayed healing and less scar tissue.

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