In the repair and regeneration stage of ligament healing, the scar matrix is composed of which collagen type?

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Multiple Choice

In the repair and regeneration stage of ligament healing, the scar matrix is composed of which collagen type?

In the repair and regeneration phase of ligament healing, the scar matrix is built as a provisional framework using type III collagen. Fibroblasts quickly lay down this thin, reticular collagen to fill the defect and form granulation tissue. It provides a scaffold for cells and new matrix but offers less tensile strength than mature ligament tissue. Over time, remodeling replaces much of this type III collagen with type I collagen, increasing strength and aligning fibers more like the original ligament. Types II and IV aren’t the primary components in this healing phase—type II is cartilage collagen, and type IV is a basement membrane component.

In the repair and regeneration phase of ligament healing, the scar matrix is built as a provisional framework using type III collagen. Fibroblasts quickly lay down this thin, reticular collagen to fill the defect and form granulation tissue. It provides a scaffold for cells and new matrix but offers less tensile strength than mature ligament tissue. Over time, remodeling replaces much of this type III collagen with type I collagen, increasing strength and aligning fibers more like the original ligament. Types II and IV aren’t the primary components in this healing phase—type II is cartilage collagen, and type IV is a basement membrane component.

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