Prepare for the Tissue Injury, Healing, and Pain Test. Utilize flashcards and multiple-choice questions with hints and explanations. Ensure you're ready for the exam!

Multiple Choice

During remodeling of ligament healing, what change occurs?

During ligament remodeling, the collagen matrix matures from a weaker, disorganized scar toward a stronger, structured tissue. The key change is that the initially laid down type III collagen is gradually replaced by type I collagen, and the collagen fibers realign to run along the direction of the tissue’s mechanical load. This realignment and maturation increase tensile strength and stiffness of the ligament, improving function. Mechanically driven remodeling helps fibers orient with strain, rather than remaining randomly organized. The other ideas don’t fit this pattern: type IV collagen isn’t the main component added in this remodeling, and end-feel typically becomes firmer, not slack, as the tissue stiffens with maturation.

During ligament remodeling, the collagen matrix matures from a weaker, disorganized scar toward a stronger, structured tissue. The key change is that the initially laid down type III collagen is gradually replaced by type I collagen, and the collagen fibers realign to run along the direction of the tissue’s mechanical load. This realignment and maturation increase tensile strength and stiffness of the ligament, improving function. Mechanically driven remodeling helps fibers orient with strain, rather than remaining randomly organized. The other ideas don’t fit this pattern: type IV collagen isn’t the main component added in this remodeling, and end-feel typically becomes firmer, not slack, as the tissue stiffens with maturation.